Posts Tagged ‘myositis’

Meeting report (part 4b): evaluating muscle function in inflammatory myopathies

1 February 2012 Leave a comment

Advances in basic experimental as well as clinical research on pathophysiological mechanisms and treatment opportunities of various rheumatoid disease conditions have been complicated or frustrated by issues like how to define a disease (i.e. proper diagnosis) and how to define measurement of treatment response (i.e. which outcome measuers should be targeted and evaluated in trials). In this blog, after putting things in a broader context shortly, I will write what I learned about evaluating disease activity of inflammatory myopathies in daily clinical practise, and to be more precise evaluating muscle functioning. Two standardised examinations are available for that purpose: the MMT-8 and the FI-2. Read more…


Meeting report (part 4a): about the shifting classification of idiopathic inflammatory myopathies

28 January 2012 3 comments

What I also heard during my 2-day visit to the Karolinska Institute at Stockholm, Sweden, was a nice overview on the current status of both classification as well as (emerging) treatment options of idiopathic inflammatory myopathies. As a clinician, three take-home messages were what I took home from this oral presentation by professor Ingrid Lundberg MD PhD (photo), who can be regarded as one of the top-experts worldwide in this field of rheumatology.
The first two of three take-home messages are nothing new at all when I search the literature, but I must admit my knowledge of inflammatory myopathies was not as up-to-date as I thought, because they were both quite new for me. They were: (1) the so familiar classification into polymyositis, dermatomyositis and inclusion body myositis is becoming rather obsolete and may be rapidly replaced by a calssification that is much more defined by which (combination of) myositis specific autoantibodies (MSAs), which I will discuss in this blog post. Read more…